Microcrystalline Cellulose 102

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Microcrystalline cellulose (MCC) is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. The most common form is used in vitamin supplements or tablets.

Typical Analysis
Physical form Fine granular White or almost white odourless powder
Colour White or almost white
Chemical Test
Solubility Insoluble in water, ethanol, ether and dilute mineral acids. Slightly soluble in sodium hydroxide solution.
Solubility in ammoniacal solution of Copper teramine Dissolves completely leaving no residue
Identification tests  
Test A The substance becomes violet blue
Test B Polymerization not more than 350
pH of solution (2 % W/V solution in CO₂ free water) 5.0 to 7.5
Starch & Dextrin No blue or brownish red colour is produced.
Ether soluble substances Max.0.05%
Water soluble substance Max.0.25%
Heavy metals Maximum 10ppm
Sulphated Ash Maximum 0.10%
Loss on drying ( 105⁰ C for 3 hrs.) Max.7.0%
Assay (dried basis) 97.0%-102.0%
Physical test  
Bulk density 0.28 to 0.34 g/cm³ (untapped)
Sieve analysis (% retention) 60 mesh-NMT 8.0%
Microbial test  
Total Aerobic Microbial Count Not more than 1000 CFU/g
Total yeasts and mould count Not more than 100 CFU/g
Escherichia coli & Salmonella Should be absent
Staphylocaccus aureus Should be absent
Pseudomonus aeruginosa Should be absent

Storage Conditions: To be stored on above ground on clean, dry & dust free godown

Packaging: 25 kgs.

Stability & Shelf Life: Stable in sealed containers stored in shady , dry, and ventilated warehouse under normal conditions.Non- hygroscopic in nature and has long shelf life.
Usage and Applications:
  • Microcrystalline Cellulose is a versatile product and used in pharmaceutical formulations as Excipient.
  • MCC is also used in food industries as an anti-caking agent and a bulking agent.
  • Microcrystalline Cellulose is derived from Wood pulp and the most common form is used in vitamin supplements or tablets.
  • MCC 101- most suitable for wet granulation and direct compression.
  • MCC 102- particle larger than 101 good flow and high compatibility , suitable for direct compression activity.
  • MCC 103-same as grade 101 but with low moisture content for processing water sensitive actives.
  • MCC 105-It has the finest particle size and may be used in direct compression of coarser , granular and crystalline materials.
  • MCC 112-Same as grade 102 but with low moisture content for processing water sensitive actives.
  • MCC 200-It has a large particle size which offers increase flow ability with minimum effect on compression characteristics.
  • MCC 301-same as grade 101but with higher bulk density & improved flow properties.
  • MCC 302-same as grade 102but with increased bulk density & increased flow properties. Suitable for high speed tableting and potential for smaller tablet.
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