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Sodium Starch Glycolate

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Sodium starch glycolate is a white to off-white, tasteless, odorless, relatively free flowing powder. Sodium starch glycolate is used as a pharmaceutical grade dissolution excipient for tablets and capsules. Sodium starch glycolate absorbs water rapidly, resulting in swelling which leads to rapid disintegration of tablets and granules. It is used as a disintegrant, a suspending agent and as a gelling agent. Without a disintegrant, tablets may not dissolve appropriately and may affect the amount of active ingredient absorbed, thereby decreasing effectiveness.

Pharmaceutical companies add sodium starch glycolate to capsules and tablets to help make them disintegrate and dissolve better, making it easier for your body to absorb the medication. It does this by absorbing water quickly so the pill swells and breaks apart into small pieces. It can also be used to help form gels.

Physical Appearance White or almost white , fine free flowing powder very hygroscopic
Test - A Infrared absorption
Test - B Changes from blue to violet colour by addition of iodine or potassium iodide
Test - C Imparts an intense yellow colour to a non luminious flame


pH
5.5-7.5
Sodium Glycolate Max 2.0%
Sodium Chloride Max. 07.0%
Iron Max.20 ppm
Heavy metals Max.20 ppm
Loss on drying Max.10.0%
Assay (% of sodium on dry basis) 2.8%-4.2%
Residual Solvents (MeoH) Max 3000 ppm
Particle size 99% passing through 100 mesh
Microbial Size  
Total Aerobic microbial count NMT 1000 CFU/g
Total yeasts & moulds count NMT 100 CFU/g
Escherichia coli Should be absent
Salmonella Should be absent

Shelf life: 4 years

Uses & Applications :
  • Is produced by cross-linking and carboxy-methylation of starch. It is white free flowing powder.
  • Used as a rapid disintegrant in pharmaceutical formulations.
  • Is suitable for a variety of tablet and capsule formulations.
  • Can act as a dissolution enhancing agent.
  • Offers excellent formulation & commercial benefits to the pharmaceutical industry.
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